Isolation and Identification of Hypotensive Principles in Red-Mold Rice(Biological)

被引用文献5件
  • 小浜 靖弘
    Faculty of Pharmaceutical Sciences, Osaka University
  • 松本 茂
    Faculty of Pharmaceutical Sciences, Osaka University
  • 三村 務
    Faculty of Pharmaceutical Sciences, Osaka University
  • 田辺 伸和
    Research and Development Dept., Gunze Limited
  • 稲田 昭
    Faculty of Pharmaceutical Sciences, Setsunan University
  • 中西 勤
    Faculty of Pharmaceutical Sciences, Setsunan University

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説明

During an initial search for pharmacologically active principles in red-mold rice, two hypotensive compounds were isolated and identified. The active principles, A-3 and B-1, were fractionated and purified from the EtOH extract of red-mold rice prepared with Monascus pilosus through extraction with H_2O, Amberlite CG-120 column chromatographies and high-performance liquid chromatography on an ODS column. A-3 was identified as acetylcholine chloride by comparison with an authentic sample, and B-1, colorless needles of mp 203-205℃, was proved to be identical with authentic γ-aminobutyric acid. Intravenously administered A-3(0.5μg/kg) and B-1(250μgAg) produced potent depression of the carotid arterial blood pressure in spontaneously hypotensive rats, as did the corresponding authentic samples.

収録刊行物

  • Chem. Pharm. Bull.

    Chem. Pharm. Bull. 35 2484-2489, 1987

    公益社団法人日本薬学会

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