Syntheses of the Acridone Alkaloid Citrusinine-I and Its Derivatives

  • KATO Nobuharu
    Central Research Laboratories, Santen Pharmaceutical Co., Ltd.,
  • FUJITA Masanobu
    Central Research Laboratories, Santen Pharmaceutical Co., Ltd.,
  • FUJIMURA Ken-ichi
    Central Research Laboratories, Santen Pharmaceutical Co., Ltd.,
  • KAWASHIMA Yoichi
    Central Research Laboratories, Santen Pharmaceutical Co., Ltd.,
  • NISHIYAMA Yukihiro
    Laboratory of Virolygy, Research Institute for Disease Mechanism and Control, Nagoya University School of Medicine

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Abstract

Citrusinine-I (1), a naturally occurring acridone alkaloid with potent anitiviral activity, was synthesized for the first time, via a route involving Ulmann reaction, cyclization, and selective demethylation at the 1-position with boron trifluoride etherate and lithium bromide. 1,5,6-Trihydroxy-3-methoxy-9(10H)-acridone (2a) and 1,5,6-trihydroxy-3-methoxy-10-methyl-9(10H)-acridone (2b) were also synthesized.

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Details 詳細情報について

  • CRID
    1572543027231042176
  • NII Article ID
    110003630425
  • NII Book ID
    AA00602100
  • ISSN
    00092363
  • Text Lang
    en
  • Data Source
    • CiNii Articles

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