Syntheses of the Acridone Alkaloid Citrusinine-I and Its Derivatives

  • 加藤 信治
    Central Research Laboratories, Santen Pharmaceutical Co., Ltd.,
  • 藤田 昌宣
    Central Research Laboratories, Santen Pharmaceutical Co., Ltd.,
  • 藤村 健一
    Central Research Laboratories, Santen Pharmaceutical Co., Ltd.,
  • 河嶋 洋一
    Central Research Laboratories, Santen Pharmaceutical Co., Ltd.,
  • 西山 幸廣
    Laboratory of Virolygy, Research Institute for Disease Mechanism and Control, Nagoya University School of Medicine

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抄録

Citrusinine-I (1), a naturally occurring acridone alkaloid with potent anitiviral activity, was synthesized for the first time, via a route involving Ulmann reaction, cyclization, and selective demethylation at the 1-position with boron trifluoride etherate and lithium bromide. 1,5,6-Trihydroxy-3-methoxy-9(10H)-acridone (2a) and 1,5,6-trihydroxy-3-methoxy-10-methyl-9(10H)-acridone (2b) were also synthesized.

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詳細情報 詳細情報について

  • CRID
    1572543027231042176
  • NII論文ID
    110003630425
  • NII書誌ID
    AA00602100
  • ISSN
    00092363
  • 本文言語コード
    en
  • データソース種別
    • CiNii Articles

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