Bioactive Saponins and Glycosides. II. Senegae Radix (2): Chemical St4ructures, Hypoglycemic Activity, and Ethanol Absorption-Inhibitory Effect of E-Senegasaponin c, Z-Senegasaponin c, and Z-Senegins II, III, IV
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- YOSHIKAWA Masayuki
- Kyoto Pharmaceutical University
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- MURAKAMI Toshiyuki
- Kyoto Pharmaceutical University
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- MATSUDA Hisashi
- Kyoto Pharmaceutical University
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- UENO Takahiro
- Kyoto Pharmaceutical University
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- KADOYA Masashi
- Kyoto Pharmaceutical University
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- YAMAHARA Johji
- Kyoto Pharmaceutical University
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- MURAKAMI Nobutoshi
- Kyoto Pharmaceutical University
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説明
Following the characterization of E-senegasaponins a and b and Z-senegasaponins a and b, new bioactive saponins named E-senegasapinin c and Z-senegasapinin c were isolated from Senegae Radix, the root of Polygala senega L. var. latifolia TORREY et GRAY., together with Z-senegins II, III, and IV. The chemical structures of E and Z-senegasaponins c and Z-senegins II, III, and IV were elucidated on the basis of chemical and physicochemical evidence, and the geometrical isomerc structures of the 4''-methoxycinnamoyl and 3'', 4''-dimethoxycinnamoyl groups in these saponins were found to show tautomer-like behavior under irradiation with fluorescent lamps.E and Z-Senegasaponins c and E and Z-senegins II, III, and IV were found to exhibit hypoglycemic activity in the oral D-glucose tolerance test. (E) and (Z)-Senegins II also showed an inhibitory effect on alcohol absorption in rats.
収録刊行物
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- Chemical & pharmaceutical bulletin
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Chemical & pharmaceutical bulletin 44 (7), 1305-1313, 1996-07-15
公益社団法人日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1572824502208655360
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- NII論文ID
- 110003632076
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- NII書誌ID
- AA00602100
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- ISSN
- 00092363
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- 本文言語コード
- en
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- データソース種別
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- CiNii Articles