Synthesis and Biological Activities of 2,3-Dimethyl-1,4-benzoquinones Having Alkylthio and Arylthio Side Chains(Medicinal Chemistry,Chemical)

1 Citations
  • MORI K.
    Faculty of Pharmaceutical Sciences, Kobe-Gakuin University
  • TAKAHASHI KYOKO
    Faculty of Pharmaceutical Sciences, Kobe-Gakuin University
  • KISHI TAKEO
    Faculty of Pharmaceutical Sciences, Kobe-Gakuin University
  • SAYO HIROTERU
    Faculty of Pharmaceutical Sciences, Kobe-Gakuin University

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Description

New 2,3-dimethyl-1,4-benzoquinones having an alkylthio or arylthio side chain at the 5-position and two alkylthio side chains at the 5- and 6-position were synthesized as possible antimetabolites of coenzyme Q. These compounds were tested for inhibition of coenzyrne Q in mitochondrial succinoxidase and reduced nicotinamide adenine dinucleotide (NADH)-pxidase systems, and were found to show greater inhibition of the NADH-oxidase system than of the succinoxidase system. 5,6-Di-octylthio-2,3-dimethyl-1,4-benzoquinone showed greater inhibitory activities than 5-alkylthio-2,3-dimethyl-1,4-benzoquinones. 5-Arylthio-2,3-dimethyl-1,4-benzoquinones showed potent inhibitory activities towards both enzyme systems.

Journal

  • Chem. Pharm. Bull.

    Chem. Pharm. Bull. 35 1270-1274, 1987

    The Pharmaceutical Society of Japan

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Details 詳細情報について

  • CRID
    1573105977138944256
  • NII Article ID
    110006281045
  • NII Book ID
    AA00602100
  • ISSN
    00092363
  • Text Lang
    en
  • Data Source
    • CiNii Articles

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