スナネズミの心耳筋細胞における心房性ナトリウム利尿ペプチド (ANP) 顆粒の加齢に伴う変化

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書誌事項

タイトル別名
  • Atrial Natriuretic Peptide (ANP) -Granules of Auricular Cardiocytes in Aging Mongolian Gerbils

抄録

The atrial natriuretic peptide (ANP) -granules of right auricular cardiocytes were studied in aging Mongolian gerbils by immunohistochemistry and transmission electron microscopy, and analyzed by ultrastructural morphometry. Immunohistochemically, the ANP immunoreactions were weaker in 3 and 4-year-old animals than in 90-day-old, 1-and 2-year-old animals. There was no difference in the reaction among 90-day-old, I and 2-year-old animals, or between 3 and 4-year-old animals. Ultrastructurally, the morphological features in 1 and 2-year-old animals were similar to those of 90-day-old animals, but distinct in 3 and 4-year old animals by the presence of a few lysosomal structures in the cell. By ultrastructual morphometry, number and diameter of ANP-granules of 3 and 4-year-old animals were significantly smaller than those in the 90-day-old, 1 and 2-year-old. There was no significant difference in number and diameter among the 90-day-old, 1 and 2-year-old, or between the 3 and 4-year-old.

収録刊行物

  • Experimental Animals

    Experimental Animals 40 (4), 573-577, 1991

    公益社団法人 日本実験動物学会

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