Synthesis of 2,3-Dihydro-1,4-benzodioxin Derivatives. I. : 2-Substituted-5(and 6)-sulfamoyl-2,3-dihydro-1,4-benzodioxins

書誌事項

公開日
1988-09-25
公開者
公益社団法人日本薬学会

この論文をさがす

説明

In order to study new sulfonamide diuretics, two series of 6- and 5-sulfamoyl-2,3-dihydro-1,4-benzodioxins were synthesized and tested for diuretic and antihypertensive activities in rats. Starting from 4-chloro(or 3,4-dichloro)-1,2-dihydroxybenzene, these sulfamoyl compounds were prepared by two different routes. In method A, 6-sulfamoyl compounds (8 or 11) were obtained by conversion of the nitro function into sulfonamide via the Sandmeyer reaction. In method B, 5-sulfamoyl compounds (16) were synthesized by direct introduction of sulfonyl chloride into the dihydrobenzodioxin, followed by amination. The sulfamoyl dihydrobenzodioxins showed lower diuretic and antihypertensive activities than trichloromethiazide.

収録刊行物

キーワード

詳細情報 詳細情報について

  • CRID
    1573387452273706752
  • NII論文ID
    110003654821
  • NII書誌ID
    AA00602100
  • ISSN
    00092363
  • 本文言語コード
    en
  • データソース種別
    • CiNii Articles

問題の指摘

ページトップへ