ISOLATION AND STRUCTURE OF REGELIN AND REGELINOL, NEW ANTITUMOR URSENE-TYPE TRITERPENOIDS FROM TRIPTERYGIUM REGELII(Communication to the Editor)

  • Hori Hitoshi
    Pharmaceutical Institute, School of Medicine, Keio University
  • Pang Guo-Mao
    Pharmaceutical Institute, School of Medicine, Keio University
  • Harimaya Kenzo
    Pharmaceutical Institute, School of Medicine, Keio University
  • Iitaka Yoichi
    Faculty of Pharmaceutical Sciences, The University of Tokyo
  • Inayama Seiichi
    Pharmaceutical Institute, School of Medicine, Keio University

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Description

Regelin (1a), a new antitumor ursene-type triterpenoid, the major principle, and another new ursene-type regelinol (1c) were isolated together with oleanene-type regelide (2) from the roots of Tripterygium regelii. The respective structures of 1a and 1c were determined, by ^1H-and ^<13>C-NMR spectrometric studies and X-ray analysis of 1a, to be the methyl ester of 3-oxo-22α-hydroxy-urs-12-en-30-oic acid and its 23-hydroxy analogue. 2 was found to be identical with wilforlide A or abruslactone A by comparing their physico-chemical data.

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