Isolation of iturin A-2 as an inhibitor of cytokinesis of starfish embryos
説明
Abstract 1. 1. We have purified substances from the bacterium Bacillus subtilis that inhibit the cell division of embryos of the starfish, Asterina pectinifera , and which are identified as iturin A-2 and closely related cyclic peptides. 2. 2. Iturin A-2 at a concentration of 12.5 μg/ml or greater inhibited cell division of the fertilized starfish egg but not nuclear division, resulting in formation of a multinueleated unicellular embryo. 3. 3. Iturin A-2 microinjected into a fertilized egg was ineffective in halting cell division. 4. 4. From the results of these experiments, we conclude that the arrest of cleavage produced by iturin A-2 is due to the inability of the cell membrane to make a furrow at cytokinesis.
収録刊行物
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- Comparative Biochemistry and Physiology Part C: Comparative Pharmacology
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Comparative Biochemistry and Physiology Part C: Comparative Pharmacology 84 381-384, 1986-01-01
Elsevier BV
