The clinically relevant CYP2C8*3 and CYP2C9*2 haplotype is inherited from Neandertals

DOI IR PubMed Open Access

Search this article

Description

Genetic variation in genes encoding cytochrome P450 enzymes influences the metabolism of drugs and endogenous compounds. The locus containing the cytochrome genes CYP2C8 and CYP2C9 on chromosome 10 exhibits linkage disequilibrium between the CYP2C8*3 and CYP2C9*2 alleles, forming a haplotype of ~300 kilobases. This haplotype is associated with altered metabolism of several drugs, most notably reduced metabolism of warfarin and phenytoin, leading to toxicity at otherwise therapeutic doses. Here we show that this haplotype is inherited from Neandertals.

source:https://www.nature.com/articles/s41397-022-00284-6

Journal

Keywords

Details 詳細情報について

Report a problem

Back to top