Tissue Plasminogen Activator in the Pathogenesis of Protein-Losing Gastroenteropathy

DOI PubMed オープンアクセス

書誌事項

公開日
1976-06-01
DOI
  • 10.1016/s0016-5085(76)80307-1
公開者
Elsevier BV

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説明

Tissue fibrinolytic activity, mainly due to activator of tissue plasminogen was increased in the biopsied gastric mucosa of patients with protein-losing gastropathy. Antiplasmin therapy with trans-AMCHA (trans-4-aminomethyl cyclohexane carboxylic acid) was dramatically effective, except in the case of a patient with intestinal lymphangiectasia. These findings suggest that increased fibrinolysis in the gastrointestinal mucosa may play an important role in enhancing mucosal permeability to plasma proteins.

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