Degradation of thyroxine by the microsomal particles from rat liver

DOI PubMed

この論文をさがす

説明

Abstract 1. 1. Particles which catalyze the degradation of l -thyroxine labeled with 131 I at the 3′ and 5′ positions in the β-ring have been isolated from rat liver microsomes and purified. 2. 2. The reaction requires Fe 2+ and protein present in microsomal particles. 3. 3. Thyroxine degradation in the above reaction is correlated with lipid peroxide formation. It may be, therefore, that the microsomal protein functions with unsaturated fatty acids present in the particles as a prosthetic group for the oxidation or hydroxylation of the β-phenyl ring of thyroxine.

収録刊行物

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ