Loss-of-function mutations in Zn-finger DNA-binding domain of

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Description

Hepatocyte nuclear factors (HNF) are transcription factors that crucially regulate cell-specific gene expression in many tissues, including the liver. Of these factors, HNF4A acts both as a master regulator of liver organogenesis and a tumor suppressor in the liver. In our whole genome sequencing analysis, we found seven somatic mutations (three Zn-finger mutations, three deletion mutants, and one intron mutation) of

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Details 詳細情報について

  • CRID
    1874242817264490368
  • ISSN
    19492553
  • PubMed
    29899848
  • Data Source
    • OpenAIRE

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