Genipin inhibits MMP-1 and MMP-3 release from TNF-α-stimulated human periodontal ligament cells

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Bibliographic Information

Title
Genipin inhibits MMP-1 and MMP-3 release from TNF-α-stimulated human periodontal ligament cells
Other Title
  • genipinはTNF-αが誘導するヒト歯根膜細胞のMMP-1およびMMP-3産生を抑制する
Author
Shindo, Satoru
Alias Name
  • 進藤, 智
  • シンドウ, サトル
Author
Hosokawa, Yoshitaka
Alias Name
  • 細川, 義隆
  • ホソカワ, ヨシタカ
Author
Hosokawa, Ikuko
Alias Name
  • 細川, 育子
  • ホソカワ, イクコ
Author
Ozaki, Kazumi
Alias Name
  • 尾崎, 和美
  • オザキ, カズミ
Author
Matsuo, Takashi
Alias Name
  • 松尾, 敬志
  • マツオ, タカシ
University
徳島大学
Types of degree
博士（歯学）
Grant ID
甲口第425号
Degree year
2017-03-23

Description

Genipin, the aglycon of geniposide found in gardenia fruit has long been considered for treatment of inflammatory diseases in traditional oriental medicine. Genipin has recently been reported to have some pharmacological functions, such as antimicrobial, antitumor, and anti-inflammatory effects. The aim of this study was to examine whether genipin could modify matrix metalloproteinase (MMP)-1 and MMP-3, which are related to the destruction of periodontal tissues in periodontal lesion, expression in tumor necrosis factor (TNF)-a-stimulated human periodontal ligament cells (HPDLCs). Genipin prevented TNF-a- mediated MMP-1 and MMP-3 productions in HPDLCs. Moreover, genipin could suppress not only extracellular signal-regulated kinase (ERK) and Jun-N-terminal kinase (JNK) phosphorylations but also AMP-activated protein kinase (AMPK) phosphorylation in TNF-a-stimulated HPDLCs. Inhibitors of ERK and AMPK could inhibit both MMP-1 and MMP-3 productions. Moreover, we revealed the ERK inhibitor suppressed AMPK phosphorylation in TNF-a-stimulated HPDLCs. These data provide a new mechanism through which genipin could be used for the treatment of periodontal disease to prevent MMPs expression in periodontal lesion.

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