Functional Role of HSP47 in the Periodontal Ligament Subjected to Occlusal Overload in Mice

DOI 機関リポジトリ NDLデジタルコレクション

書誌事項

タイトル
Functional Role of HSP47 in the Periodontal Ligament Subjected to Occlusal Overload in Mice
タイトル別名
  • マウス歯根膜における咬合過重負荷時のHSP47 の機能的役割
著者
三村, 泰亮
著者
Mimura, Hiroaki
著者
Takaya, Tatsuo
著者
Matsuda, Saeka
著者
Nakano, Keisuke
著者
Muraoka, Rina
著者
Tomida, Mihoko
著者
Okafuji, Norimasa
著者
Fujii, Takeo
著者
Kawakami, Toshiyuki
学位授与大学
松本歯科大学
取得学位
博士（歯学）
学位授与番号
甲第203号
学位授与年月日
2017-02-09

説明

We carried out an experiment to induce traumatic occlusion in mice periodontal tissue and analyzed the expression of HSP47. Continuous traumatic occlusion resulted to damage and remodeling of periodontal ligament as well as increase in osteoclasts and bone resorption. Four days after traumatic occlusion, osteoclasts did not increase but Howship’s lacunae became enlarged. That is, the persistent occlusal overload can destroy collagen fibers in the periodontal ligament. This was evident by the increased in HSP47 expression with the occlusal overload. HSP47 is maintained in fibroblasts for repair of damaged collagen fibers. On the other hand, osteoclasts continue to increase although the load was released. The osteoclasts that appeared on the alveolar bone surface were likely due to sustained activity. The increase in osteoclasts was estimated to occur after load application at day 4. HSP47 continued to increase until day 6 in experiment 2 but then reduced at day 10. Therefore, HSP47 appears after a period of certain activities to repair damaged collagen fibers, and the activity was returned to a state of equilibrium at day 30 with significantly diminished expression. Thus, the results suggest that HSP47 is actively involved in homeostasis of periodontal tissue subjected to occlusal overload.

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