重症筋無力症胸腺におけるニコチン性アセチルコリン受容体とFasの発現について : 免疫組織化学的検討

機関リポジトリ (HANDLE)

メタデータ

タイトル別名
  • Fas and Nicotinic Acetylcholine Receptor in Human Myasthenic Thymus: Immunohistochemical Study
公開日
1999-06-25
資源種別
journal article
権利情報
  • 本資料は権利関係や内容に配慮し、本文を非公開にしています。閲覧をご希望の場合は冊子体をご利用ください。
  • Due to considerations regarding rights and content, the full text is not available for public access.. Please use the printed version.
  • 『福岡医学雑誌』の利用について
  • Regarding the Use of "Fukuoka Acta Medica"
アクセス権
非共有・非公開
URLリンク
巻
90
号
6
ページ
286-294
公開者
Fukuoka Medical Association
データ作成者 (e-Rad)
  • 川浪, 祥子 (70037472)
  • 森, 尚一郎
  • 菊池, 昌弘 (80078774)
  • 白日, 高歩 (20038863)

説明

We studied the immunohistochemical localization of Fas and nicotinic acetylcholine receptor (nAChR) in the human thymus with myasthenia gravis (MG). Thymuses were obtained from thirteen patients with MG, (thymic hyperplasia 8; thymoma 5) and six normal controls. Antibodies against Fas, nAChR protein isolated from fetal calf thymus (nAChR-FCT), CD3, CD4, and CDS were used. In both hyperplastic thymus and controls, Fas antigen was found in medullary epithelial cells especially in those around Hassall's corpuscle, in subcapsular epithelial cells, and partially in the cortex. There were no apparent differences between myasthenic thymus and the controls. In the thymic medulla the anti-nAChR-FCT antibody showed a similar staining pattern to the antibody against Fas. The nAChR and the Fas were suggested to be present in the same cell. Then six thymomas were double immunostained with antibodies against Fas and nAChR-FCT. A part of neoplastic epithelial cells were double positive for both Fas and nAChR. The present results show the first observation on the colocalization of the Fas and nAChR in thymic epithelial cells. These antigens were supposed to work on triggering mechanism of autoimmunity in MG.

収録刊行物

  • 福岡醫學雜誌

    福岡醫學雜誌 90 (6), 286-294, 1999-06-25

    Fukuoka Medical Association

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