Development of in silico human model and its application to indoor environmental design
-
- Ito Kazuhide
- Principal Investigator
- 九州大学
About this project
- Japan Grant Number
- JP18H03807
- Funding Program
- Grants-in-Aid for Scientific Research
- Funding organization
- Japan Society for the Promotion of Science
- Project/Area Number
- 18H03807
- Research Category
- Grant-in-Aid for Scientific Research (A)
- Allocation Type
-
- Single-year Grants
- Review Section / Research Field
-
- Medium-sized Section 23:Architecture, building engineering, and related fields
- Research Institution
-
- Kyushu University
- Project Period (FY)
- 2018-04-01 〜 2022-03-31
- Project Status
- Completed
- Budget Amount*help
- 42,250,000 Yen (Direct Cost: 32,500,000 Yen Indirect Cost: 9,750,000 Yen)
Research Abstract
We developed an in silico human model to visualize health risk associated with exposure to contaminated indoor air. In particular, we developed numerical models that can predict inhalation exposure in respiratory tract and dermal exposure by deposition of gas-phase contaminant. Specifically, (1)we newly developed physiologically based pharmacokinetic/toxicokinetic models that reproduce inhalation exposure and dermal exposure, and (2)these models were integrated into the in silico human model that precisely reproduced body surface and respiratory tract geometry. (3) We also established a comprehensive analysis method for human-environment systems that integrates in silico human model and computational fluid dynamics (CFD) technique. Finally, (4)we conducted demonstrative analyses for e-cigarette smoking in an indoor environment and showed quantitatively the potential effects of e-cigarette smoking on local tissue dosimetry and the deterioration of indoor air quality.
Keywords
Details 詳細情報について
-
- CRID
- 1040000781994121856
-
- Text Lang
- ja
-
- Data Source
-
- KAKEN