A novel amorphous preparation improved curcumin bioavailability in healthy volunteers: A single-dose, double-blind, two-way crossover study

DOI Web Site Web Site 被引用文献7件 参考文献32件 オープンアクセス

書誌事項

公開日
2021-06
資源種別
journal article
権利情報
  • https://www.elsevier.com/tdm/userlicense/1.0/
  • https://www.elsevier.com/legal/tdmrep-license
  • http://creativecommons.org/licenses/by/4.0/
DOI
  • 10.1016/j.jff.2021.104443
公開者
Elsevier BV

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説明

Curcumin derived from Curcuma longa has beneficial pharmacological effects. However, its bioavailability is very low. To improve its bioavailability, we developed a novel amorphous formulation of curcumin, called curcuRougeTM. We investigated the bioavailability of curcuRougeTM and compared its efficiency with that of Theracurmin®. Male Sprague–Dawley rats were orally administered curcuRougeTM or Theracurmin® (10 mg/kg of curcumin). Based on the area under the plasma concentration-time curve, the bioavailability of curcuRougeTM was 3.7-fold higher than that of Theracurmin® in rats. We performed a single-dose, double-blind, two-way crossover study to compare the bioavailability of curcuRougeTM and Theracurmin® (90 mg of curcumin) in 12 volunteers (8 males, 4 females). The bioavailability of curcuRougeTM was 3.4-fold higher than that of Theracurmin®. curcuRougeTM achieved Cmax in a shorter time than Theracurmin® in both experiments. These findings indicate that curcuRougeTM, an amorphous formulation of curcumin, shows superior bioavailability to that of Theracurmin®.

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