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Effect of L-Arabinose on Blood Glucose Level after Ingestion of Sucrose-containing Food in Human.

  • Inoue Shuji
    Division of Geriatric Health and Nutrition, National Institute of Health and Nutrition
  • Sanai Kazuko
    Enzymes & Pharmaceuticals Research Laboratory, Godo Shusei Co., Ltd.
  • Seri Kenji
    Enzymes & Pharmaceuticals Research Laboratory, Godo Shusei Co., Ltd.

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  • ヒトにおけるショ糖含有食品摂取後の血糖上昇に及ぼすL‐アラビノースの作用
  • ヒト ニ オケル ショ トウ ガンユウ ショクヒン セッシュ ゴ ノ ケットウ ジョウショウ ニ オヨボス L アラビノース ノ サヨウ

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Abstract

L-Arabinose selectively inhibits intestinal sucrase activity in vitro and suppresses the glycemic response in a dose-dependent manner in experimental animals. In the present study, we investigated the effect of L-arabinose on the glycemic response of healthy volunteers and patients with type 2 diabetes. In the first experiment using a cross-over design, eight fasted normal volunteers were each given 50g of sucrose with and without 2g of L-arabinose. The increases of plasma glucose and serum insulin were significantly lower in the individuals given both L-arabinose and sugar. In the second experiment, the dose-dependency of L-arabinose was evaluated. Forty normal volunteers over 40 years old were given a jelly containing 30g of sucrose with added L-arabinose in ratios of 0%, 2%, 3% and 4% (w/w)(n=10). L-Arabinose at 3% and 4% significantly suppressed the increase of plasma glucose at 30min after ingestion. In the third experiment, patients with type 2 diabetes (n=10) were given the jelly with 3% (w/w) added L-arabinose using a cross-over design. L-Arabinose suppressed the maximal increase of plasma glucose after sucrose ingestion. These results demonstrate that L-arabinose attenuates sucrose-induced hyperglycemia both in normal subjects and diabetic patients, presumably through inhibition of intestinal sucrase activity.

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