Efficacy of vaginal progesterone for preventing preterm birth in women with singleton pregnancies with prior spontaneous preterm birth or second-trimester miscarriage

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  • Sato Yuka
    Department of Obstetrics and Gynecology, Graduate School of Medical Sciences, Kyushu University
  • Hidaka Nobuhiro
    Department of Obstetrics and Gynecology, Graduate School of Medical Sciences, Kyushu University Department of Obstetrics, Fukuoka Children’s Hospital
  • Sakai Atsuhiko
    Department of Obstetrics and Gynecology, Graduate School of Medical Sciences, Kyushu University
  • Kido Saki
    Department of Obstetrics and Gynecology, Graduate School of Medical Sciences, Kyushu University
  • Fujita Yasuyuki
    Department of Obstetrics and Gynecology, Graduate School of Medical Sciences, Kyushu University
  • Inoue Hirosuke
    Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University
  • Ochiai Masayuki
    Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University
  • Ohga Shouichi
    Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University
  • Kato Kiyoko
    Department of Obstetrics and Gynecology, Graduate School of Medical Sciences, Kyushu University

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Other Title
  • 流早産既往を有する早産ハイリスク妊娠におけるプロゲステロン腟坐剤の早産予防効果の検証

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<p> This is a prospective interventional study to evaluate whether vaginal progesterone（VP）reduces spontaneous preterm birth（sPTB）incidence in pregnant Japanese women with prior spontaneous second-trimester miscarriages（sSTM）or sPTB. The VP group were included singleton pregnancies with prior sSTM or sPTB. VP was administered to the participants between 16+0 and 33+6 weeks of gestation. Maternal background, perinatal outcomes were investigated for eligible patients and compared with the historical control outcomes among participants with singleton pregnancies with prior sSTM or sPTB managed without VP. The main outcome was the incidence of sPTB ＜ 36 weeks of gestation. A total of 79 and 76 pregnancies in the VP and control groups were analyzed. The incidences of prior sSTM and prior sPTB ＜ 28 weeks of gestation were significantly higher in the VP group, and the median earliest gestational ages for prior sSTM and sPTB were significantly earlier in the VP group. The incidence of sPTB ＜ 36 weeks of gestation was lower in the VP group（8.9%）than in the control group（17.1%）. The study findings suggest the possible benefits of VP in reducing the recurrent sPTB.</p>

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