Effect of "Flammulina velutipes extracts" on decrease the lipid accumulation using rat visceral adipocyte culture system

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  • エノキタケ抽出物のラット初代前駆内臓脂肪細胞での脂肪蓄積抑制効果
  • エノキタケ チュウシュツブツ ノ ラット ショダイ ゼンク ナイゾウ シボウ サイボウ デ ノ シボウ チクセキ ヨクセイ コウカ

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Abstract

Clinical studies in humans have reported that the intake of dietary Flammulina velutipes (Curt.: Fr.) Singer extracts results in a significant decrease in the visceral fat area as measured by computed tomography. The fatty acid composition of F.velutipes extracts was found to include constituents that bind to cells expressing the β-adrenoceptor. Here, we investigated the effect of F.velutipes extracts on lipid accumulation in primary culture of rat visceral adipocytes. Morphological examination showed a marked reduction in lipid droplets compared with the control, demonstrating an inhibitory effect on lipid accumulation. The triglyceride (TG) to DNA ratio in cells after the culturing with F.velutipes extract was significantly lower. These findings suggest that F.velutipes extracts have an inhibitory effect on visceral fat accumulation.

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