書誌事項
- タイトル別名
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- Suppressive Effect on Tumor Metastasis by 6-(methylsulfinyl) hexyl isothiocyanates from Wasabi.
- ジッケン テンイ シュヨウケイ ニ ヨル サワ ワサビ セイブン 6 methylsulfinyl hexyl isothiocyanate ノ テンイ ヨクセイ コウカ
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抄録
A highly metastatic Balb/c mouse cell line, r/m HM-SFME-1, is established from transformed ras/myc SFME cell line carrying active human c-Ha-ras genes. Metastasis was measured by detection of the amount of the PCR products of c-Ha-ras gene from cancer cells which had been inoculated at foot-pad of mice. A standard curve was made using r/m HM SFME-1 cell DNAs. The amount of PCR products corresponding to 123bp was measured by Bioimage Analyzer. First, we examined the suppressive effect of 6-(methylsulfinyl) hexyl isothiocyanate (6-MITC) against dissemination of tumor cells to kidney of experimental animals at day 9 of inoculation. TNP-470 which has been reported to be effective to the angiogenesis, 4-(methylsulfinyl) butyl isothiocyanate (4-MITC) from broccoli and 6-MITC were administrated to the experimental mice. The 6-MITC of wasabi was more effective than other two chemicals. Then, 6-MITC (40 or 400μM) was fed orally by mixing with drinking water to examine the suppressive effect of tumor metastasis. No visible alteration of body weight was observed by the administration of 6-MITC. All of the control mice revealed human c-Ha-ras bands. In animals fed 40μM 6-MITC, all of the lungs provided human c-Ha-ras bands. Four out of five mice administrated 400μM 6-MITC provided no detectable bands showing no metastasis, however, and only faint band was observable in one mouse lung. Thus, it was suggested that 6-MITC suppressed dissemination or metastasis of tumor cells with oral administration.
収録刊行物
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- 日本食品科学工学会誌
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日本食品科学工学会誌 47 (10), 760-766, 2000
公益社団法人 日本食品科学工学会
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詳細情報 詳細情報について
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- CRID
- 1390282681385539072
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- NII論文ID
- 10007576562
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- NII書誌ID
- AN10467499
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- COI
- 1:CAS:528:DC%2BD3cXnsFOjt7w%3D
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- ISSN
- 18816681
- 1341027X
- http://id.crossref.org/issn/1341027X
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- NDL書誌ID
- 5512239
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可