Design of cell adhesive/non-adhesive synthetic polymers by controlling the nanobiointerfacial water

Tanaka Masaru

doi:10.2745/dds.38.404

When materials come into contact with biological fluids, water immediately adsorb onto the surface of materials. Water molecules play a crucial role in nanobiointerfacial interactions, including protein adsorption/desorption and cell adhesion/deadhesion on materials. To understand the role of water in the interaction of proteins and cells at biological interfaces, it is important to compare particular states of hydration water with various physicochemical properties of hydrated materials. Here, we discuss the fundamental concepts for determining the interactions of proteins and cells with hydrated materials along with selected examples corresponding to our recent studies, poly（2-methoxyethyl acrylate）（PMEA）, PMEA derivatives, zwitterionic polymers, poly（ethylene glycol）, and poly（2-oxazoline）s, and other polymers including biopolymers （DNA, RNA, proteins, and polysaccharides）. The states of water were analyzed by differential scanning calorimetry, time-resolved in situ attenuated total reflection infrared spectroscopy, solid-states NMR, surface force measurements, and wide variety of analytical techniques. We found that intermediate water which is loosely bound to a polymer, is a useful indicator of the biocompatibility of polymer surfaces. This finding on intermediate water provides novel insights and helps develop novel experimental models for understanding protein adsorption/cell adhesion in a wide range of polymers, and helps guiding principles to design functional polymers such as those used in biomedical applications.

Design of cell adhesive/non-adhesive synthetic polymers by controlling the nanobiointerfacial water

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